Abstract:
This research communication is toward the investigation of microwave synthesis and biological evaluation of 3-(tetrahydro-3,4,5-trihydroxy-6-hydroxymethyl-2H-pyran-2-yloxy)-2-aryl/heteroaryl-4H-chromones (3-O-β-D-glucopyranosyloxyflavones). These compounds have been obtained by the interaction of α-acetobromoglucose with 3-hydroxy-2-aryl/heteroaryl-4H-chromones under microwave condition. The structures of these newly synthesized 3-O-β-D-glucopyranosides were established on the basis of chemical, elemental, and spectral analyses. Further, All compounds were evaluated for antimicrobial activity. The inhibition caused by 3-hydroxy flavones was relatively low whereas that of its 3-O-β-D-glucopyranosides analogues was substantially more.
Keywords: Flavones, 3-O-β-D-glucopyranosides, microwave irradiation, antimicrobial.